The ideal amount of PRP platelets hasn't been determined yet, however generally, the optimal level of platelets for osteoarthritis in the knee, as well as tendinopathies, is a range of 3-4x increase in platelets in the baseline. A study in which 33 PRP protocols were tested, but only 11 of them met the criteria of PRP having a minimum platelet count of 1,000,000/mL, or 5x the baseline concentration.
In reality, three of the 33 protocols and systems evaluated had a final PRP product that had less platelet count than the total blood count. EmCyte kits in NJ have produced PRP with an average platelet concentration of 7x baseline, with some studies showing an increase of greater than 9x baseline concentration. You can buy Emcyte PRP in NJ from https://5linebiologics.com/platelet-rich-plasma/ for pure PRP concentration.
This range of variability illustrates the importance of choosing the right system and adherence to protocol. When analyzing commercial kits, Emcyte PurePRP GenesisCS is the one with the highest level of platelet count (Fadadu and colleagues, 2019). EmCyte kits have created PRP that has an average platelet count of 7x baseline as mentioned above.
Giving the right amount of platelets is the pillar of PRP therapy and that is one of the main reasons why we utilize the Emcyte system. Other factors to consider include the number of white blood cells (WBCs) as well as red blood cells (RBCs).
The inclusion of WBCs is not a consensus for tendinopathy, however, it is widely accepted that WBCs can have a negative impact on the healing of cartilage in joints and shouldn't be considered in the treatment of osteoarthritis. The majority of commercial kits do not dramatically reduce WBC count.